{"id":418,"date":"2024-06-05T20:00:00","date_gmt":"2024-06-05T20:00:00","guid":{"rendered":"https:\/\/www.snijderlab.org\/news\/?p=418"},"modified":"2024-09-26T13:41:16","modified_gmt":"2024-09-26T13:41:16","slug":"t-cell-architecture-science","status":"publish","type":"post","link":"https:\/\/www.snijderlab.org\/news\/2024\/06\/05\/t-cell-architecture-science\/","title":{"rendered":"T cell architecture @ Science"},"content":{"rendered":"\n

Did you know that most of the T cells in your blood are Stripy? Stripy T cells (abbreviated as T\u00d8<\/sub>) are small round T cells with a deep nuclear invagination that spatially concentrates the ER, Golgi, mitochondria, and an intracellular pool of T cell receptors. Now, in our latest paper just out in Science<\/a>, Ben<\/a> and the team, in collaboration with the wonderful labs from Annette Oxenius<\/a> and the Blutspende Zurich<\/a>, show that the way a T cell looks (their “architecture”) matters greatly for its function!<\/p>\n\n\n\n

\"\"<\/a><\/figure>\n\n\n\n

Because of their spatial organization, stripy T cells are fast responders and predominantly turn into effector cells, while conventional looking T cells (abbreviated as TO<\/sub>; i.e. those T cells without nuclear invaginations and therefore without cytoplasmic content bundling) respond slower, more muted, and predominantly give rise to memory precursor cells. Read all about it in Science<\/a>!<\/p>\n\n\n\n

Also check out the ETH News article<\/a>, the Tweetorial by the lab<\/a>, and the many amazing videos embedded in the publication, including this one!<\/p>\n\n\n\n

This discovery was an unexpected offshoot from our multiplexed immune cell imaging by Yannik<\/a> previously published in Science Advances<\/a> and Nature<\/a>, all funded by the Swiss National Science Foundation<\/a> \u2764\ufe0f.<\/p>\n","protected":false},"excerpt":{"rendered":"

Did you know that most of the T cells in your blood are Stripy? Stripy T cells (abbreviated as T\u00d8) are small round T cells with a deep nuclear invagination that spatially concentrates the ER, Golgi, mitochondria, and an intracellular pool of T cell receptors. Now, in our latest paper just out in Science, Ben… Continue reading T cell architecture @ Science<\/span> →<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1,5],"tags":[],"class_list":["post-418","post","type-post","status-publish","format-standard","hentry","category-news","category-publications"],"_links":{"self":[{"href":"https:\/\/www.snijderlab.org\/news\/wp-json\/wp\/v2\/posts\/418","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.snijderlab.org\/news\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.snijderlab.org\/news\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.snijderlab.org\/news\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.snijderlab.org\/news\/wp-json\/wp\/v2\/comments?post=418"}],"version-history":[{"count":10,"href":"https:\/\/www.snijderlab.org\/news\/wp-json\/wp\/v2\/posts\/418\/revisions"}],"predecessor-version":[{"id":439,"href":"https:\/\/www.snijderlab.org\/news\/wp-json\/wp\/v2\/posts\/418\/revisions\/439"}],"wp:attachment":[{"href":"https:\/\/www.snijderlab.org\/news\/wp-json\/wp\/v2\/media?parent=418"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.snijderlab.org\/news\/wp-json\/wp\/v2\/categories?post=418"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.snijderlab.org\/news\/wp-json\/wp\/v2\/tags?post=418"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}