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Welcome to the Snijder Lab.

We use systems biology to discover things about cells.

Clinical trial! Learn More
Research

Measure. Integrate. Analyze. Validate.

The list doesn't stop there, but it's the essence of what we do, and we love it. Nothing beats the thrill of discovery, and as a bonus we sometimes discover things that contribute to human wellbeing.

Measure

Our lab specializes in automated microscopy, which allows us to take many pictures of cells doing their thing in different conditions. We use image analysis and machine learning to make sense of the results.

Integrate

We integrate our results with different OMICS datasets, such as gene and protein expression, and lipid abundance data, to reveal the molecular systems at work.

Analyze

Big data analysis is key to identify the critical signals and build predictive quantitative models. Sometimes available methods fall short and we end up developing new statistical methods.

Validate

All models we build should tell us something that we did not know before. This can send us into unexpected directions, such as enabling us to predict the responses of patient samples to different signals.

Pharmacoscopy

Bringing automated microscopy to the clinic.

Together with a great team of people at the Center for Molecular Medicine, the Medical University of Vienna, and the University Hospital of Zurich we are working hard on bringing the power of automated microscopy to the clinic. We call the technology Pharmacoscopy.

Our first pharmacoscopy clinical trial appeared in 2017 in The Lancet Haematology! We find that Pharmacoscopy can help identify effective treatments for patients suffering aggressive haematological malignancies.
Great commentary: "A precision medicine approach to haematological malignancies".


We published our first pharmacoscopy paper in 2017 in Nature Chemical Biology, on quantifying the immunomodulatory action of drugs in blood cells of individual donors.

Personalized

Using Pharmacoscopy we can test hundreds of drugs on small blood or tissue samples from individual people, and actually see what each drug does to each individual donor cell, be it healthy or cancerous.

Predictive

Powerful

The single-cell resolution allows to compare drug killing of cancer cells with that of healthy donor cells, and to measure the drug-effects on immune-mediated cancer cell killing, ensuring we identify potent treatments.

Flexible

Pharmacoscopy uses the same markers that clinicians use to diagnose different cancers, and it is compatible with blood samples, bone-marrow biopsies, and excised lymph nodes, making the technology widely applicable.

Fast

Unlike many competing methods to identify optimal therapies for individual patients, Pharmacoscopy produces results within days from getting the sample, meaning we can be helpful also in accute circumstances.

Efficient

From small patient and donor biopsies Pharmacoscopy can measure thousands of different conditions, allowing us to test many drugs in repeat tests and at different concentrations.

Team Members

We are hiring.

We are always looking for highly motivated people to join our team!
Get in touch if you are interested.


The Snijder Lab on top of the Uetliberg in May 2017:

 
 
 
 
 

 
 
 
 
 

 
 
 
 
 

 
 
 
 
 

 
 
 
 
 

Postdoc

This could be you!

We are looking for new and/or experienced postdocs wanting to drive the analysis of human-to-human variability by image-based screening and integrative lipidomics and genomics of human samples in the area of immunology and hemato-oncology.

Apply now

Master Student

This could be you!

We are looking for master students interested in joining the lab for projects in image analysis, machine learning, network analysis, computational biology, image-based screening, and personalized medicine.

Apply now

Check out some of our research higlights:

Faq

Questions and Answers.

Still not clear who we are and what we do? Or do you have other questions? Perhaps your questions are answered below, but don't hesitate to contact us if they're not.

What are you?

We are a publicly funded laboratory headed by Prof. Dr. Berend Snijder at the Institute of Molecular Systems Biology of the ETH Zurich in Switzerland. We are Systems Biologists, which in practice means that we combine large-scale cell biological experimentation with big data analysis and computational modeling. We do this to improve our ability to measure key aspects of cell biology, and to improve our understanding of life in health and disease.


Who funds you?

Our research is supported by public funding, which means we have a strong mandate to give back to society. Our current funders are:

What web comics do you enjoy?

I'm glad you asked. We enjoy several great web comics that are all mostly safe for work:

How can I apply to your lab?

We are always looking for enthusiastic people to join our team. Check the members section, we currently have several vacancies that we are looking to fill. Please apply by e-mailing your CV and an explanation of your motivation to Berend Snijder.

Publications

Check our publication list.


Get in touch with us.

We are planning big things. You too? Let's work together!